Description
Topical analgesic Capsidol When capsicin is used topically, it causes a local irritation that manifests as erythema and a burning feeling that can be irritating. The release of the substance P neurotransmitter is thought to be the cause of this impact, which is connected to a neurogenic inflammatory process. In a second phase, capsaicin’s action is linked to antinociceptive effects that last anywhere from a few hours to weeks. The depletion of substance P from the neuron causes a long-term reduction of sensitivity to burning and pain after repeated application.
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